Corpus downloaded from PubMed 18th May: 13103 publications. There were 1861 keywords that occurred in three or more manuscripts. These divided into four main clusters.
This week’s rapport strengthens our observation from last couple of weeks that the clusters and topics seem to vary less, signifying that cluster may be more robust. This is true even if cluster 1 and 2 have changed places. Maybe this switch could imply that research and publication is switching more to how to managing the disease, than mainly be focused on the understanding of the phenomenon. In cluster 3 the term(s) (hydroxyl)chloroquine is rising on the list. Last week there was a fifth cluster that we called “clinical issues”, but the terms included in this cluster have returned to the third cluster where they originated.
Cluster 1 could be called “disease epidemiology” and includes terms like pneumonia, epidemiology, outbreak, infection, infectious diseases, novel coronavirus pneumonia, treatment and transmission. This cluster contains 2 major topics: a) the main term “the disease” which in addition to the above mentioned terms, but also b) “inpatient care” which contains terms like ARDS, critical illness and airway management. In this cluster some smaller topics are also present.
Cluster 2 could be called «global virus pandemic» and includes terms (beta)coronavirus infection, viral pneumonia, pandemic/epidemic, public health, infection control and quarantine. This cluster contains 3 main topics a) “preventive epidemiology”, which in addition to the terms public health and quarantine contains terms like disease outbreak, travel and contact tracing, b) “care management” which includes terms like infection control, practice guidelines and health personnel and c) “vulnerability” that contains terms like mental health, psychological stress and health service accessibility.
Cluster 3 could be called “pathophysiology and origin” and includes terms like SARS, animals, zoonosis, antiviral agents, viral genome, phylogeny and chiroptera. This cluster contains to major topics: a) “viral biology” which in addition to terms like SARS, animals, viral genome and phylogeny includes terms like spike glycoprotein and peptidyl-dipeptidase a and b) “drug treatment” which in addition to the term antiviral agent, (hydroxyl)chloroquine and chiroptera contains terms like traditional Chinese medicine and lopinavir.
Cluster 4 could be named “clinical epidemiology” and contains terms like mortality, age, gender, clinical laboratory techniques and fever. Also in this cluster, there is only this major topic. Smaller topics include “population care”, “serology” and “pregnancy”.
Table of the most central keywords in each cluster
(Centrality measure used is weighted degree centrality)
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 |
| pneumonia | coronavirus infection | sars | female |
| epidemiology | viral pneumonia | animals | male |
| outbreak | pandemic | antiviral agents | adult |
| viruses | betacoronavirus | peptidyl-dipeptidase a | middle aged |
| infection | china | zoonosis | clinical laboratory techniques |
| infectious diseases | disease outbreaks | spike glycoprotein, coronavirus | aged |
| mortality | public health | genome, viral | young adult |
| treatment | infection control | hydroxychloroquine | tomography, x-ray computed |
| critical illness | travel | viral vaccines | children |
| respiratory infections | quarantine | chloroquine | adolescent |
| transmission | epidemic | phylogeny | lung |
| diagnosis | global health | antibodies, viral | risk factor |
| prevention | united states | chiroptera | retrospective studies |
| novel coronavirus pneumonia | italy | clinical trials as topic | fever |
| ards | health personnel | middle east respiratory syndrome coronavirus | aged, 80 and over |
| virology | personal protective equipment | ace2 | infant |
| influenza | practice guidelines as topic | receptors, virus | cough |
| guidelines | time factors | wuhan | child, preschool |
| japan | telemedicine | cardiovascular diseases | comorbidity |
| therapy | mental health | inflammation | real-time polymerase chain reaction |
| acute respiratory distress syndrome | contact tracing | mers | severity of illness index |
| telehealth | world health organization | angiotensin-converting enzyme inhibitors | pregnancy |
| immunosuppression | united kingdom | immunization, passive | surveys and questionnaires |
| lymphopenia | infectious disease transmission, patient-to-professional | lopinavir | hospitalization |
| respiratory tract infections | critical care | hypertension | prognosis |
Cluster description in progress
To open the map directly in VOSviewer, please use these two files.
KeywordCoOccurrance3Inst1Resol20200518MAP
KeywordCoOccurrance3Inst1Resol20200518NET
The maps are created with the following “thesaurus” to clean the data:
KeywordCoOccurrance_20200427_Thesaurus